1995Acute coronary syndromesDiabetes & obesity620 patients

DIGAMI

Therapy group: Glucose control · Therapy: Insulin

In diabetic patients with acute myocardial infarction, insulin-glucose infusion followed by subcutaneous insulin reduced long-term mortality.

Published in J Am Coll Cardiol (1995)

Question: Does an insulin-glucose infusion followed by multidose subcutaneous insulin reduce long-term mortality in diabetic patients with acute myocardial infarction?
Design: Randomized trial of 620 diabetic patients with acute myocardial infarction, with mortality followed over 12 months.
Population: Patients with diabetes presenting with acute myocardial infarction.
Intervention: Insulin-glucose infusion followed by multidose subcutaneous insulin treatment for at least 3 months (306 patients).
Control: Conventional therapy (314 patients).
Primary outcome: All-cause mortality during the 12 months after randomization.
Results: At 1 year, 57 patients (18.6%) in the infusion group and 82 (26.1%) in the control group had died, a 29% relative mortality reduction (p = 0.027). The benefit was particularly evident in low cardiovascular risk patients without prior insulin treatment (1-year mortality 8.6% vs. 18.0%; 52% relative reduction, p = 0.020).
Conclusion: Insulin-glucose infusion followed by a multidose insulin regimen improved long-term prognosis in diabetic patients with acute myocardial infarction.
Why it matters: It was one of the first demonstrations that intensive metabolic control in the acute phase of myocardial infarction could improve survival in people with diabetes, and it spurred interest in glycemic management in acute coronary syndromes.

Card generated automatically with AI from the abstract of the original publication and the trial registry; every figure was checked against those sources. It may contain errors: verify the data at the source before using it for clinical decisions.

Generated on October 10, 2026

Sources

Original publication on PubMed (PMID 7797776) ↗Randomized trial of insulin-glucose infusion followed by subcutaneous insulin treatment in diabetic patients with acute myocardial infarction (DIGAMI study): effects on mortality at 1 year.
Journal article (DOI) ↗

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